Showing posts with label bariatric obstetrics. Show all posts
Showing posts with label bariatric obstetrics. Show all posts

Monday, January 21, 2019

Metformin Use in Nondiabetic Obese Pregnancy

Article from The Daily Mail, 2011

One of the strongest concerns doctors have about pregnancies in the "obese" is that larger people tend to have larger (macrosomic) babies. Although most macrosomic babies are born just fine, they do have higher rates of shoulder dystocia (babies who get stuck) and related injuries, as well as low blood sugar at birth and more cesareans. So doctors want to do everything they can to prevent abnormally big babies.

Some macrosomia is tied to high blood sugar and high insulin levels. So in hopes of preventing big babies, doctors have been using the diabetes medication, metformin, in those diagnosed with Gestational Diabetes (GD) or Polcystic Ovarian Syndrome (PCOS).

A number of studies have confirmed that metformin use in women with GD does modestly reduce the rate of big babies. It also lowers the rate of early pregnancy loss and prematurity in PCOS. More research is needed but metformin does seem to be a very helpful drug for people with GD or PCOS. No one is questioning this use of metformin.

However, the use of metformin in obese women WITHOUT gestational diabetes or PCOS is a different story. Doctors note that even high BMI people who are not diabetic have larger babies on average. So the working theory has been that these women must be pre-diabetic or have strong insulin resistance that increases fetal size.

So doctors began prescribing metformin to nondiabetic obese women in hopes that lowering insulin levels and borderline blood sugar would cut the odds of a big baby.

The practice was aggressively marketed to the public as a way to prevent "obese babies" before its research was even completed (see headlines quoted here from The Daily Mail 2011 and 2012).

But what does the research say about this use of metformin? Here is a quick summary of the three largest trials.

The Studies on Non-Diabetic High BMI Women

From article in the Daily Mail, 2012
Chiswick 2015

Several years ago, a large study called the EMPOWaR trial (Chiswick 2015) tested this theory in the U.K.

This study involved 15 hospitals and was a large, randomized, double-blind placebo-controlled trial, the gold standard of research. It had n=434 participants with a BMI over 30 for analysis. The maximum metformin dose was 2500 mg.

To authors' great surprise, they found that metformin did NOT lower neonatal size.

Syngelaki 2016

Some common criticisms of the EMPOWaR study were that the metformin dose was too low, the participants weren't fat enough to show any big effect, and they did not take doses strictly enough.

Therefore, in a subsequent study published in the prestigious New England Journal of Medicine (Syngelaki 2016, the MOP trial), n=400 participants were limited to those with a BMI over 35. This study, too, was a randomized, double-blind study with placebo controls and was more racially diverse.

The researchers increased the metformin dose to a maximum of 3000 mg and made sure there was strong adherence to the medication. By limiting the analysis to those with a BMI over 35, increasing the dosage, including more women of color, and making sure metformin was consistently used, the authors hoped to show more of an effect.

To their surprise, results were again similar. While the metformin group had a slightly lower weight gain, fetal size was the same between groups.

Dodd 2019

Researchers just can't leave this theory alone.

Now there is a new study (the GRoW trial) out, also testing the metformin theory (Dodd 2019). This trial was done in Australia and included women with a BMI over 25 (in other words, both "overweight" and "obese"). No previous study had included those in the overweight category.

This also was a gold standard randomized study, n=514 participants. It used doses of up to 2000 mg.

It also found slightly less weight gain in the metformin group but NO difference in birthweight of the babies.

Research Summary

There have been a few other, small studies about metformin use in nondiabetic women, but none have been as large or as strong as these studies. No study so far has found that metformin lowers neonatal birthweight in nondiabetic women. That message is very clear and consistent.

There were other outcomes that weren't as clear. Some, but not all, studies found a mild lowering of prenatal weight gain. Some found decreased incidence of preeclampsia, while others did not. No other outcomes were routinely affected.

At this point, the hypothesis that metformin will "normalize" the size of high BMI women's babies has pretty well been disproven. I'm sure there will be more studies on it because the theory is a favorite of many OBs, but these are strong studies and frankly, I doubt they'll be overturned.

The good news is that no babies seem to have been harmed in these studies. However, many of the mothers experienced significant gastrointestinal side effects from the metformin and this some caused drop-outs or scaled-back dosing. If you've ever taken metformin, you know the G.I. effects can be considerable. This certainly affects people's quality of life. As a result, it's not something that should be prescribed lightly.

The take-home message from research: Metformin is a great drug that can be useful for some indications (like GD or PCOS) but in nondiabetic high BMI women it does not lower neonatal birthweight. As the authors of the EMPOWaR study concluded:
... metformin should not be used to improve pregnancy outcomes in obese women without diabetes.
The Fat-Shaming Around These Studies

Illustration from the 2012 Daily Mail article
It has to be pointed out that the U.K. public health campaign around these studies was glaringly fat-shaming.

Look at the caption above. Fat women are accused of letting their babies be "born obese," of passing on their toxic obesity in the womb through their carelessness about their health. They use the classic picture of a fat body with the head cut off, depersonalizing the subject. The person is even holding a roll of fat, pointing out visual blame so the negative message is even clearer. 

The articles were filled with scary summaries of the risks of obesity and pregnancy, without any context for those risks, how often they don't happen, and what can be done about them when they do. It's not unreasonable to inform women of size of the possible risks around weight and pregnancy, but it's another thing to misrepresent those risks to scare or shame women out of pregnancy.

The campaign was attempting to inflame the public about irresponsible fat people, implying that they refuse to be healthy and are costing the NHS huge amounts of money, taking money away from everyone else. The U.K. is a very fat-phobic place and the government is scapegoating fat people for their healthcare budget woes.

The language of the campaign was also offensive. They used the terms "fat babies" or "obese babies" in order to shame the mothers, but a big baby is not necessarily the same as an "obese" baby. They are conflating fetal size caused by diabetic complications with big babies that are simply larger than average.

All big babies are not alike. Some babies are big because of blood sugar issues, and these babies do tend to be abnormally proportioned and have more issues at birth. On the other hand, some babies are just naturally larger without it being pathological. There is a significant difference between a diabetic's baby that is 9 lbs. but only 16 inches long and a 9 lb. baby that is 22 inches long. The first is abnormal and a true concern; the second is proportional and most likely genetic. The first type often has problems being born safely and has many complications; the second type of big baby is proportional and can usually be born vaginally.

Furthermore, the campaign is simplistic and misleading. Not all obese mothers have macrosomic babies; one study found that only 17% of obese women had macrosomic babies while 83% of them did NOT. Subjecting all obese women to metformin "just in case" means medicating many people who wouldn't produce a big baby anyhow. What potential harm might that be doing?

Some people of average size also have macrosomic babies without blood sugar or insulin issues; no one knows why some babies are bigger than others. And many big babies do have vaginal births; Navti 2007 found that 83% of women who had babies around 10 pounds or more were able to have vaginal births. This shows that even very big babies can often be born vaginally, given time, patience, sufficient mobility, and a calm caregiver. We need to stop panicking over babies that are larger than average and save our intervention for those who truly need it.

Researchers: Stop trying to put the baby on a diet before it is even born. Metformin for reducing fetal size does not work in nondiabetics. 

Public Health Campaigns: Stop promoting weight stigma and fat-shaming in your campaigns about obesity and pregnancy. 



References

Lancet Diabetes Endocrinol. 2019 Jan;7(1):15-24. doi: 10.1016/S2213-8587(18)30310-3. Epub 2018 Dec 4. Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. Dodd JM, Louise J, Deussen AR, Grivell RM, Dekker G, McPhee AJ, Hague W.  PMID: 30528218
... GRoW was a multicentre, randomised, double-blind, placebo-controlled trial in which pregnant women at 10-20 weeks' gestation with a BMI of 25 kg/m2 or higher were recruited from three public maternity units in Adelaide, SA, Australia. Women were randomly assigned (1:1) via a computer-generated schedule to receive either metformin (to a maximum dose of 2000 mg per day) or matching placebo. Participants, their antenatal care providers, and research staff (including outcome assessors) were masked to treatment allocation...  FINDINGS: Of 524 women who were randomly assigned between May, 28 2013 and April 26, 2016, 514 were included in outcome analyses (256 in the metformin group and 258 in the placebo group). Median gestational age at trial entry was 16·29 weeks (IQR 14·43-18·00) and median BMI was 32·32 kg/m2 (28·90-37·10); 167 (32%) participants were overweight and 347 (68%) were obese. There was no significant difference in the proportion of infants with birthweight greater than 4000 g (40 [16%] with metformin vs 37 [14%] with placebo; adjusted risk ratio [aRR] 0·97, 95% CI 0·65 to 1·47; p=0·899). Women receiving metformin had lower average weekly gestational weight gain (adjusted mean difference -0·08 kg, 95% CI -0·14 to -0·02; p=0·007) and were more likely to have gestational weight gain below recommendations (aRR 1·46, 95% CI 1·10 to 1·94; p=0·008). ... INTERPRETATION: For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes.
N Engl J Med. 2016 Feb 4;374(5):434-43.doi: 10.1056/NEJMoa1509819. Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus. Syngelaki A, Nicolaides KH, Balani J, Hyer S, Akolekar R, Kotecha R, Pastides A, Shehata H. PMID: 26840133
[kmom summary] Randomized double-blind, placebo controlled trial. Limited to those with BMI over 35 and upped the metformin dosage. Less preeclampsia and less weight gain in metformin group but no difference in birth weight. "CONCLUSIONS: Among women without diabetes who had a BMI of more than 35, the antenatal administration of metformin reduced maternal weight gain but not neonatal birth weight."
Lancet Diabetes Endocrinol. 2015 Oct;3(10):778-86. doi: 10.1016/S2213-8587(15)00219-3. Epub 2015 Jul 9. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. Chiswick C, Reynolds RM, Denison F, Drake AJ, Forbes S, Newby DE, Walker BR, Quenby S, Wray S, Weeks A, Lashen H, Rodriguez A, Murray G, Whyte S, Norman JE. PMID: 26165398 Free full text here.
[kmom summary] Randomized placebo-controlled, double-blind study in 15 hospitals in the U.K. on nondiabetic women. Results: "Metformin has no significant effect on birthweight percentile in obese pregnant women."
Previous discussion of these studies and others:
Metformin for Gestational Diabetes or PCOS

J Matern Fetal Neonatal Med. 2018 Nov 20:1-141. doi: 10.1080/14767058.2018.1550480. [Epub ahead of print] Metformin-treated-GDM has lower risk of macrosomia compared to diet-treated GDM- A retrospective cohort study. Bashir M, Aboulfotouh M, Dabbous Z, Mokhtar M, Siddique M, Wahba R, Ibrahim A, Al-Houda Brich S, Konje JC, Abou-Samra AB. PMID: 30458653
...This is a retrospective cohort study that included GDM women compared to normoglycaemic controls between March 2015-December 2016 in the Women's Hospital, Qatar. RESULTS: The study included 2221 women; of which 1420 were normoglycaemic, and 801 were GDM (358 GDM-D and 443 GDM-T)... Women in the GDM-T group had lower GWG/week compared to GDM-D (-0.01 ± 0.7 versus 0.21 ± 0.51 kg/week; p < 0.001). After correcting for age, prepregnancy weight and GWG; GDM-T had higher risk of preterm labour (OR 1.66; 95% CI 1.20-2.22), and C-section (OR 1.37, 95% CI 1.02-1.85) and reduced risk of macrosomia (OR 0.56; 95% CI 0.32-0.96) and neonatal hypoglycaemia (OR 0.49; 95% CI 0.28-0.82). CONCLUSION: ... Treatment with metformin reduces maternal weight gain, the risk of macrosomia and neonatal hypoglycaemia compared to diet alone.
J Clin Endocrinol Metab. 2010 Dec;95(12):E448-55. doi: 10.1210/jc.2010-0853. Epub 2010 Oct 6. Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. Vanky E et al.  PMID: 20926533
[kmom summary] n=274 PCOS pregnancies. Randomized controlled trial with placebos. Less prematurity, but more pre-eclampsia in metformin group. Less weight gain in metformin group. No difference in fetal size between groups.  

Saturday, January 12, 2019

Induction: Don't Break The Waters Early

Amnihooks, which are used to artificially break a woman's waters

New research (Pasko 2018) suggests that when care providers induce high BMI women, they should NOT break the waters in early labor (early amniotomy), especially in first-time mothers.

Breaking the waters early is commonly done to speed up labor. Sometimes it is done to place an internal monitor to monitor the baby more easily, but usually it is used to intensify contractions and shorten labor. Caregivers assume that this will help obese women avoid a cesarean.

However, the results from this new study suggest that early amniotomy actually increases the risk for a cesarean instead.

Study Details

In this retrospective cohort study, women with Class III "obesity" (body mass index ≥40 kg/m2) who were being induced  (n=285) were placed into two groups.

The first group (n=107) received early amniotomy before 4 cm dilation, and the other group (n=178) received late amniotomy.

The group who received early amniotomy had double the cesarean risk of those who did received later amniotomy.

In first-time (nulliparous) mothers, the risk for cesarean was tripled with early amniotomy. 

The length of labor was not shortened in either group. So the whole justification for using early amniotomy (shorter labor, fewer cesareans) for obese women was irrelevant.

An older study (Sheiner 2000) which examined induction by early amniotomy concluded:
In order to decrease the CS rates, induction should probably start with cervical ripening techniques in order to improve the Bishop scores.
Bishop Scores are a measure of how ripe and ready for labor the cervix is. Inductions on an unripe cervix are more likely to fail and result in cesarean, especially in first-time moms. Bishop scores tend to be lower at the start of inductions in women of size, which is probably an important factor in higher weight women's induction failures. 

Women of size also tend to have longer labors and generally take longer in latent (early) labor before reaching active labor. Yet despite this, research shows that early amniotomy is used more often in higher weight women. This needs to change.

How can early amniotomy (also known as Artificial Rupture of Membranes or early AROM) affect labor? When the water is broken, the cushioning around the baby is removed. Labor becomes much more painful, and there is risk for infection. The baby may be more likely to experience an abnormal heart rate (distress). If the baby is not well-positioned when AROM occurs, then the baby can become stuck in that position and have difficult getting out (labor dystocia). These factors can add up and result in a cesarean.

The take-home message from this study on high BMI women is obvious: Avoid having your waters broken before active labor begins (now defined as at least 6 cm dilation). This is especially important if you are a first-time mother. 

Of course, parents have to remain flexible in labor; plans may need to change. For example, if baby may be in trouble and external monitoring is not working well, then breaking the water sooner to place an internal monitor may make sense. But most of the time, amniotomy should not be done early in labor, especially in obese first-time mothers.

Induction Hints

It is best to await spontaneous labor whenever possible, so always question whether an induction is truly necessary. However, it's a hard truth that sometimes induction of labor does become medically necessary. If so, there are some lessons from research that may lessen your risk for cesarean. Most apply to women of all sizes but may be particularly relevant for higher weight women.

Ask your provider about your Bishop Score; if your cervix isn't ripe (Bishop score <5), ask if the induction can be delayed. If it cannot be delayed, ask for techniques to help ripen the cervix before pitocin is started and realize that you may need more time to reach active labor. Some research suggests that Foley catheter or prostaglandin (PGE2) inductions may be more effective in women of size than misoprostol (Cytotec).

Women of size may also need a larger dose of pitocin to keep an induced labor going strong, but this must be done cautiously because too much pitocin can send the baby into fetal distress. Wait and see how you and baby respond before increasing the dosage and go slowly with any adjustments.

Be sure you have a care provider who understands that latent labor tends to take longer in higher weight women and will give you plenty of time. Many cesareans in women of size are done before active labor, and many could probably be prevented if caregivers were more patient and waited longer before moving to a cesarean.

Be sure your baby is in an optimal position for birth before the induction if possible. Chiropractic care may help align the pelvis and maximize the space for an easier birth. If the baby is posterior (facing your front) in labor, ask your caregiver for manual rotation, which clearly reduces the risk for cesarean in several studies.

Maintain your mobility as much as possible and don't get stuck in bed on your back. Make gravity work for you. Upright positions reduce the length of labor and the risk for cesarean. Special positions like hands and knees or an exaggerated Sims position may help malpositioned babies turn more easily. You can read more aboutvarious labor and birth positions here.

As discussed, don't let the caregivers break the waters until you are well into active labor. If possible, let the waters break on their own. Keeping the waters intact as long as possible can help a malpositioned baby turn more easily.

Hire a doula to give professional labor support. One study found a cesarean rate of 13.4% in a group of first-time mothers with doulas, whereas the cesarean rate in the group without doulas was 25%. The difference was even more marked in those whose labors were induced; the group with doulas had a cesarean rate of 12.5%, vs. a 58.8% rate in those without doulas.

These ideas should improve your chances of a normal vaginal birth with an induction. Of course there are no guarantees, but rest assured that with enough time and patience, a reasonably ripe cervix, a well-positioned baby, and good support, many inductions in women of size can result in vaginal births.



Reference

Am J Perinatol. 2018 Nov 5. doi: 10.1055/s-0038-1675331. [Epub ahead of print] Pregnancy Outcomes after Early Amniotomy among Class III Obese Gravidas Undergoing Induction of Labor. Pasko DN, Miller KM, Jauk VC, Subramaniam A.  PMID: 30396229 
OBJECTIVE: We sought to evaluate differences in pregnancy outcomes following early amniotomy in women with class III obesity (body mass index ≥40 kg/m2) undergoing induction of labor. STUDY DESIGN: This is a retrospective cohort study of women with class III obesity undergoing term induction of labor from January 2007 to February 2013. Early amniotomy was defined as artificial membrane rupture at less than 4 cm cervical dilation. The primary outcome was cesarean delivery. Secondary outcomes included length of labor, a maternal morbidity composite, and a neonatal morbidity composite. A subgroup analysis examined the effect of parity. Multivariable logistic regression was used to adjust for covariates. RESULTS: Of 285 women meeting inclusion criteria, 107 (37.5%) underwent early amniotomy and 178 (62.5%) underwent late amniotomy. Early amniotomy was associated with cesarean delivery after multivariable adjustments (adjusted odds ratio [aOR], 2.05; 95% confidence interval [CI], 1.21-3.47). There were no significant differences in length of labor or maternal and neonatal morbidity between groups. When stratified by parity, early amniotomy was associated with increased cesarean delivery (aOR, 3.10; 95% CI, 1.47-6.58) only in nulliparous women. CONCLUSION: Early amniotomy among class III obese women, especially nulliparous women, undergoing labor induction may be associated with an increased risk of cesarean delivery.


Friday, August 24, 2018

Study: Pre-Conception Screening with Higher Weight Women

In 2017, researchers from Harvard Medical School and the Brigham & Women's Hospital published a study on pre-conception consults with "obese" women and the outcomes of those consults. This study pointed out a couple of glaring problems with pre-conception consults for women of size, but as always, the authors ended up focusing on the wrong problem. 

Study Details

The consults were mostly done for women with fertility concerns who were seeking fertility treatment. 28% had a pre-existing diagnosis of Polycystic Ovarian Syndrome (PCOS), which often leads to sub-fertility in women of size. These consults were not with regular OBs or midwives; these consults were with Maternal-Fetal Medicine (MFM) specialists, who mainly see complicated or extra risky pregnancies. If anyone should have gotten pre-conception counseling right, it should have been these docs. But what researchers found were significant problems.

The researchers reviewed the charts of 162 consults between 2008 and 2014. They were looking for 3 main things in the records:
  1. Documentation of discussion of obesity-related risks and complications
  2. Documentation that lab tests were performed to be sure blood pressure and blood sugar were normal
  3. Whether doctors advised weight loss before pregnancy, whether people took the weight loss advice via consults with the hospital's Weight Management Program, bariatric surgery, or other programs, and if so, how much weight was lost
Discussion of Obesity-Related Risks

Unsurprisingly, doctors talked about obesity-related risks in 96% of the MFM consults. With all the emphasis in the media and in the research about the risks of obesity in pregnancy, that's to be expected. We can only hope this was done in a neutral and fair way, rather than through scare-mongering and exaggeration, but there's not much information on how the risks were presented.

Discussion of potential risks is part of a medical professional's job, so no one is suggesting that this should not have been covered. But how they discuss risk matters. Is it done in a gloom-and-doom way, is it shaming or condescending, or is it simply information provided without judgment? Do doctors emphasize ways to mitigate risk beyond losing weight? Are risk ratios the only method used (which tends to inflate the perception of risk) or are actual numerical incidences used? Do doctors acknowledge that complications are not a foregone conclusion and that many women of size can have normal pregnancies and healthy babies?

Risk discussions about weight are difficult and can be fraught with emotions. Shaming and scolding backfire because most people stop listening and tune out. Most people of size have experienced such negative contacts with healthcare professionals that they have learned to block out the gloom-and-doom predictions. Exaggerating the risk results in people not taking the discussion seriously and not listening to the important advice that might be given on prevention.

We need a different way to discuss risk surrounding weight in pregnancy. Couch the discussion in neutral terms without being judgmental. Use actual incidence figures to give numerical context to risk ratios, and make sure patients understand the difference. Acknowledge that positive outcomes are possible, and suggest ways (beyond just focus on the scale) to mitigate the risk. This is much more empowering to women and more likely to be heard and heeded. Potential complications can be discussed, but with explanations of how such problems would be addressed whenever possible. Don't center the entire discussion around weight; encourage good habits like regular exercise without tying it to the scale.

Screening for Diabetes and High Blood Pressure

Part of every preconception consult for people of size should be measuring blood sugar and blood pressure. High blood sugar in early pregnancy is strongly tied to birth defects. High blood pressure issues in pregnancy often lead to too-small babies, premature births, and sometimes even death for mother or baby.  Discovering these conditions before pregnancy and getting them under control before conception can definitely improve outcomes.

Shockingly, only about half of obese women were screened for diabetes and high blood pressure at the MFM consult:
Screening for diabetes and hypertension occurred in 48% and 51% of consults, respectively.
This is very surprising, and a tremendous missed opportunity. While most obese women do not have diabetes or blood pressure issues before pregnancy, some certainly do, and those pregnancies are responsible for much of the less ideal outcomes from high BMI pregnancies.

A preconception consult is the perfect time to discover whether there are pre-existing problems, take action, and hopefully prevent some of the worst-case scenarios. Therefore it's stunning that MFM specialists screened only half of the people of size for these conditions ahead of time.

This is the most important finding of this study, in my opinion. Medical professionals need to be sure to test for these conditions before pregnancy whenever  possible. People of all sizes should have their blood pressure taken (with the correct-sized cuff) and a medical history taken. People who are at increased risk for diabetes (such as higher-weight people, people with PCOS, people with a strong family history of diabetes, etc.) should also have their blood sugar tested pre-conception if possible.

If your care provider does not order these tests in your regular check-ups, then you need to take matters in your own hands and arrange for them to be done. Even if you are not planning a pregnancy, many pregnancies occur unplanned. Getting regular monitoring of your blood sugar levels and blood pressure if you are sexually active is simply common sense. So is taking a prenatal vitamin regularly.

Weight Loss Advice and Follow-Through

Because most doctors are taught that weight loss is the main way to prevent complications in high BMI women, advice to lose weight before pregnancy is common. The authors state:
Ideally, an MFM consult should not only inform an obese woman of the impact of her weight on fertility and pregnancy, but also equip her with strategies for weight loss.
In fact, it is that hospital's policy that all women with a BMI over 40 who are seeking fertility treatment should be automatically referred to the hospital's Weight Management program, "which includes calorie-controlled diet and liquid diet programs in addition to other medical treatments for obesity."

With a protocol like this in place, it's understandable that the researchers were disappointed that weight loss referrals weren't universally given in the consults. Just over half of participants were documented as having received advice on diet and exercise. As BMI went up, more were given such advice, as well as referrals to bariatric surgery, but it was by no means universal even at the largest sizes.

Researchers were shocked by how few women took active measures to lose weight. In the study,
27% of patients saw a nutritionist, 6% saw a provider for a medically supervised weight loss program, and 6% underwent bariatric surgery... The median weight change was a loss of 2.0 lb, or 0.6% body weight, over a median of 12 months.... Rates of any pregnancy and of ongoing pregnancy were not associated with whether women lost ≥5% body weight.
The authors of the study acknowledge that most women, especially those facing fertility challenges, don't want to delay treatment for the elusive dream of losing weight, and that this likely was why most patients did not opt into the Weight Management or bariatric surgery programs. Most began fertility treatments within a month or so after their MFM consult.

It should also be pointed out that the median weight change was TWO POUNDS... not exactly outstanding results. Those who waited and lost more than 5% of body weight did not have more pregnancies, calling into question whether weight loss is as effective for fertility as doctors assume.

But of course doctors ignored these findings and just called for more weight loss emphasis in pre-conception consults. The authors state:
...the consults were unsuccessful in meaningfully effecting pre-pregnancy weight loss. In this study, only 19% of the participants with follow-up weights achieved ≥5% loss, and only 5% achieved ≥10% loss. We believe that increased emphasis is needed on weight loss resources, including discussion of lifestyle modification and referrals to specialty obesity treatment services, e.g. bariatric surgery. In addition, MFM providers and referring REI providers must be allied in counseling women to delay fertility treatment and conception to focus on weight loss. This recommendation is more nuanced in the case of women of advanced maternal age, when postponing fertility treatment may result in loss of the fertile window and may therefore be untenable. ...More emphasis is needed on weight loss resources and delaying pregnancy to achieve weight loss goals.
Here we go, back to the same old medical mentality. It's all about losing weight before pursuing pregnancy, even when they can see that most women are not interested in that, even when most women lost very little weight despite trying, and even when such weight loss may not make a difference in live birth rates.

It's like doctors are incapable of thinking outside the box. They know the colossal failure of weight loss programs but are in such denial they cannot admit that these basically useless. Instead, their answer is MORE emphasis on weight loss programs, with a fallback to bariatric surgery if all else fails.

It is telling that no acknowledgement was made of many people's long history of dieting ups and downs and the tremendous frustration of yo-yo dieting. Many patients are just done with radical weight loss programs because they know that they are not effective long-term and they are not willing to live like that.

Like most in the weight loss field, these researchers remained determinedly obtuse. It's weight loss above everything else, at any cost. And while some higher weight people are interested in this, many are not.

Discussion of Study

It's clear from the summary at the end of the paper that the main result of this study is going to be an increased pressure on MFM specialists to push weight loss before treatment. More pressure will be brought on doctors to refer patients to the hospital's Weight Management and bariatric surgery programs. The question is whether women will be free to accept or decline these programs at will.

It's one thing to offer someone access to weight management programs; some want this and that's their choice. It's another thing to browbeat women into these programs, and it's a completely different thing to require them. While this center did not deny higher BMI women access to fertility treatment without weight loss first, that seems to be the direction they are heading, and that's alarming.

Although these hospitals deny a profit motive, let's not forget that weight loss programs are big money-makers for hospitals, so financial incentives may also play a role. The weight loss industry is BIG BUSINESS and many doctors are utterly compromised by their ties to these programs. They may be unconsciously biased and not even recognize it. Ties to the pharmaceutical industry are treated with far more caution than ties to the weight loss industry, but money talks in the bariatric field as loudly as any other.

The biggest take-away from this study should not be that more emphasis on weight loss before pregnancy is needed. 

Instead, the most important take-away SHOULD be the fact that medical professionals are not adequately testing to make sure the woman is in reasonable health before pregnancy. 

The fact that only HALF of the women were not even tested for blood pressure and blood sugar issues, yet the study authors conclude that weight loss referral is the most pressing issue shows that medical professionals are too narrowly focused on the scale. They have blinders on and cannot see anything else.

Weight should not be used as a surrogate for whether a person is healthy. Instead, documentation of blood pressure and blood sugar and other labs should be done, and treatment of any problems initiated or adjusted if needed. That will likely have more downstream improvement of outcome than trying to ensure that all the women lose at least 10% of their bodyweight first.

That doesn't mean that lifestyle and health habits should be ignored. Instead, people's individual habits should be evaluated in a non-judgmental manner, and suggestions for improvements can be gently made to people of all sizes. Advice about nutrition doesn't have to be about restricting calories; combining proteins with carbs and limiting high glycemic index carbs may help prevent some complications without necessarily resulting in weight loss. Exercise can strongly improve outcomes, even if it doesn't lead to weight loss. Lab tests can be run to see if any particular nutrients are deficient and need boosting. Nutritional consults can be very useful if they are done right.

In the study, 27% of women were willing to see a nutritionist before pregnancy, while only 6% were willing to enroll in a Weight Management program. That means there is an opportunity here for a Health At Every Size® approach instead, which would emphasize healthy habits and food, regular exercise, and lab tests as measures of health instead of the scale. This may do more to improve outcome than trying to get women to lose 10% or more of their bodyweight.

Doctors need more tools in their maternal obesity toolbox besides weight loss. They need to think about prevention beyond just losing weight before pregnancy.

Testing for pre-existing conditions before pregnancy is a cornerstone of the toolbox. Too bad these researchers missed the bus on emphasizing this as their main message.



Reference

Fertil Res Pract. 2017 Jan 13;3:3. doi: 10.1186/s40738-016-0030-9. eCollection 2017. Preconception consultations with Maternal Fetal Medicine for obese women: a retrospective chart review. Page CM, Ginsburg ES, Goldman RH, Zera CA. PMID: 28620542  Full text here.
...The purpose of this study was to evaluate the quality and effectiveness of Maternal Fetal Medicine (MFM) preconception consults for obese women. METHODS: We performed a retrospective chart review examining 162 consults at an academic medical center from 2008 to 2014. The main outcome measures included consultation content - e.g. discussion of obesity-related pregnancy complications, screening for comorbidities, and referrals for weight loss interventions - and weight loss. RESULTS: Screening for diabetes and hypertension occurred in 48% and 51% of consults, respectively. Discussion of obesity-related pregnancy complications was documented in 96% of consults. During follow-up (median 11 months), 27% of patients saw a nutritionist, 6% saw a provider for a medically supervised weight loss program, and 6% underwent bariatric surgery. The median weight change was a loss of 0.6% body weight. CONCLUSIONS: In this discovery cohort, a large proportion of MFM preconception consultations lacked appropriate screening for obesity-related comorbidities. While the vast majority of consultations included a discussion of potential pregnancy complications, relatively few patients achieved significant weight loss. More emphasis is needed on weight loss resources and delaying pregnancy to achieve weight loss goals.

Sunday, August 12, 2018

The Turkey Awards: Obesity Eugenics via Fertility Treatment Denial


We've been talking about Obesity Eugenics, when authorities try to keep people of size from reproducing through negative media campaigns, scare tactics, risk hyperbole, apocryphal stories, push for normal BMI before conception, and pressure for sterilization or termination. This incredibly insensitive and discriminatory movement is the winner of not one, but two Turkey Awards. It's time to call out these egregious practices.

If you aren't familiar with them, the Turkey Awards are the "prizes" I hand out to highlight fat-phobic treatment of people of size from care providers, biased attitudes or studies from researchers, or troubling trends in the care of fat pregnant women these days.

Last year's Turkey Award was delayed so I'm doing two years in a row now. I've already done the first half; attention to the Obesity Eugenics Media Campaign. Now it's time to highlight the egregious lack of access to fertility treatment for people of size.

In past years, we've talked about:
We've already seen in the previous Turkey Award that many care providers believe that "obese" women have no business being pregnant. As a result, there has been a concerted public health campaign in recent years to reduce pregnancies in high BMI women. Today we talk about one of the most widely accepted and insidious ways the medical establishment promotes Obesity Eugenics ─ by denying access to fertility treatment.

Lack of Access to Fertility Treatment

Headline from The Hamilton Spectator, 2011
Denying access to fertility treatment via BMI restrictions is a widely-accepted practice in the medical community. It is driven by risk hyperbole, economics, and weight bias.
“Fat women only have babies because we can’t stop them; we’re certainly not going to help you conceive.” – Family Practice doctor to woman dealing with infertility
In many fertility clinics these days, women above a certain BMI are not permitted to access fertility treatments. In many clinics the cutoff is a BMI of 35, but in the U.K., the limit is usually a BMI of 30. Here is one story of a woman denied fertility treatment and pressured for bariatric surgery because of her weight.
The first thing out of the gynaecologist's mouth was “How much do you weigh”. 135kg [297 lbs]. “Do you realise how obese you are?” I then told her I have been working hard to lose weight through diet and exercise, thinking to cut her off before she got into her fat-bashing rant. As I explained that I had lost 15kg since January, was doing 90 minutes of cardio at the gym 5 times a week, and eating a low GI, low-fat, low-carb diet. She rolled her eyes at me in disbelief. Her reply was, “You are too fat for a baby. You need to get down to 65kg [143 lbs.] before I will help you”. At that point I should have stood up, told her to go f*** herself and walked out but I was stunned. I guess she took the stunned silence as agreement because then she whipped out the lapbanding pamphlet and told me I had to have weight loss surgery. 
Stories abound of women denied fertility treatment because of weight. One woman was told by her Reproductive Endocrinologist (RE):
Pregnancy is supposed to be beautiful and natural and it can be neither at your weight. I suggest you lose 100 pounds then come back.
Here is a story from the comments section of the defunct blog, My OB Said What?!?:
I...had an amazing RE last time, but she has since retired and the only one in town will not treat me due to my weight. He will not do any infertility treatment on you unless you have a BMI under 30!! Really? Because last time I got pregnant with injections and IUI [Intrauterine Insemination] I was 330!!! I had an amazing pregnancy and a healthy baby! Why is okay that...because I have a medical issue and disease I do not deserve to have children. UGH! I can’t even start on how this way of thinking pisses me off!!
Another woman in the same story wrote in the comments section:
We have a good ob/gyn...but we cannot find a reproductive endocrinologist who will even agree to see us.
BMI limits on fertility treatment is one of the most accepted ways doctors try to keep obese women from reproducing. It's another step on the path towards Obesity Eugenics.

The PCOS Conundrum



It's true that heavier women have higher rates of fertility problems. However, it's important to note that just because you are larger, it doesn't mean you will have trouble having a baby. Lots of plus-size women have babies without help. That includes me; I was told I would probably not conceive without fertility help, but conceived four children naturally with no problems. So don't just assume (or let your doctors tell you) that if you are fat you probably won't be able to have kids.

But it's important to acknowledge that some high BMI women do have more difficulty conceiving a pregnancy. Doctors often blame higher levels of estrogen, but the bottom line is that many fertility issues in women of size can be traced back to PolyCystic Ovarian Syndrome (PCOS), which leads to higher levels of estrogen.

In PCOS, women have a hormonal imbalance, probably because of underlying insulin resistance due to impaired insulin signaling. They have too much estrogen and testosterone, but not enough progesterone. As a result, the body ovulates sporadically, weakly, or sometimes only rarely. Ovarian follicles containing eggs either don't finish ovulating or ovulate only weakly. The ovarian cysts that are a byproduct of this process give off excess hormones, and can cause distressing symptoms like excess facial and body hair, thinning scalp hair, cystic acne, body tags, darkened skin around the back of the neck, armpits, etc. It also leads to reduced fertility.

In PCOS, the woman often experiences erratic menstrual cycles, which make it difficult to become pregnant. She may not ovulate regularly, or if she does, she may ovulate only weakly. If she does manage to conceive, she may have difficulty sustaining the pregnancy because of low levels of progesterone to support the the early weeks of pregnancy. In other words, the problem may be conceiving a pregnancy, or a high miscarriage rate afterwards, or both. While there are some women with PCOS who have the ovulatory phenotype and do not have problems conceiving (I'm one of these), many women with PCOS have fertility issues.

PCOS is one of the most common cause of fertility issues. Australian research suggests that up to 72% of women with PCOS have fertility issues, and PCOS often leads to long-term weight gain due to insulin resistance. While many people with PCOS are heavy, not all are, but the fertility effects of PCOS are independent of BMI. Thin women with PCOS experience fertility problems too, but they are able to access fertility help more easily than their heavier sisters.

There is an erroneous belief among some doctors that being fat or gaining weight can cause PCOS. This is an unproven assumption based on fatphobia and allows doctors to blame women with PCOS for their condition. It is far more likely to be the opposite ─ PCOS is most likely an inherited underlying metabolic condition that then triggers weight gain. One review states:
Familial aggregation of PCOS strongly supports a genetic susceptibility to this disorder.
Weight gain does tend to make PCOS symptoms worse, but it is likely the underlying condition that causes weight gain in the first place. Although it is not impossible to lose weight with PCOS, it is much harder. And not everyone who loses weight with PCOS finds that it helps their symptoms. Many people spend years yo-yo dieting because it is so difficult to lose weight with PCOS.

It is a cruel irony to then deny heavy women with PCOS access to fertility treatment. It is a double blow because they are the very ones who need help the most. It's simply a genetic condition that is inherited through no fault of their own, but they are being punished for that genetic inheritance.

Treatment Success Rates

Headline from The Globe and Mail, 2011
Many infertility doctors justify denying fertility treatment to obese people because they contend it is less likely to succeed at high BMIs, and the risk for complications if pregnancy occurs is too high. Let's take a look at these arguments and see if they hold up.

To be fair, there is considerable research that suggests lower rates of Assisted Reproductive Technology (ART) ) success in heavier women and a higher rate of miscarriage after fertility treatment, although not all studies agree. These results seem to confirm that health issues like PCOS play a strong role in infertility in obese women. But it doesn't mean that these women should be penalized for their genetic vulnerabilities.

It's probably true that a higher BMI has a generally lower success rate of fertility treatment to regulate menstrual cycles and help ovulation occur, but that doesn't always translate to actual live birth rates. When looking at live birth rates, some research has found very similar rates of ART success in obese women. One recent Israeli study found similar pregnancy and live-birth rates between all BMI groups and concluded:
The results of our relatively large retrospective study did not demonstrate a significant impact of BMI on the ART cycle outcome. Therefore, BMI should not be a basis for IVF [In Vitro Fertilization] treatment denial.
When funds are limited, doctors argue that fertility treatment should be limited to those most likely to achieve a pregnancy. However, even when funds are available or people pay for their own treatment, many fertility doctors withhold treatment for people of size. It's not just about saving money.

Most tellingly, doctors do not deny fertility treatments to other groups (like older women) who may have lower success rates. Only obese people are penalized like this. 

This is a form of selective discrimination. If older women have access to fertility treatment, so should high BMI people.

What About Weight Loss Before Fertility Treatment?

Image from The Unnecessarean
One of the arguments for BMI limits in fertility treatment is that losing weight first improves outcomes. The British NHS Guidelines state that "most overweight women would only need to lose 5 to 10 per cent of their body weight before they would be able to conceive without needing treatment." The advantage of this is that it could save lots of money and increase success rates. However, the evidence is not so clear.

Some research does suggest higher rates of ovulation in obese women with PCOS who lose weight before fertility treatment. This is why many doctors require that high BMI people lose weight before treatment is permitted. They figure a low-cost intervention like this is worth trying before resorting to high-cost ones. That is a logical argument.

However, while weight loss may improve ovulation and pregnancy rates, does it really result in more babies? What is most important is the final outcome, i.e. live-birth rates. And not all studies agree that weight loss improves actual live-birth rates. A 2017 review found:
The existing data from randomized trials...have failed to document improved live-birth rates after the [weight loss] intervention compared with control groups.
A study in infertility clinics across several Nordic countries found statistically similar live birth rates among obese women (BMI 30-35) who were subjected to a very-low-calorie liquid diet for 3 months before In Vitro Fertilization (IVF). Another study found that an intensive weight loss intervention before IVF actually resulted in decreased IVF success.

An important 2016 study in the New England Journal of Medicine found that live birth rates were actually slightly better in the non-weight loss group that proceeded directly to fertility treatment than in the group subjected to a 6 month "lifestyle intervention" program (i.e. weight loss) before treatment:
...The primary outcome [live births] occurred in 27.1% of the women in the intervention [weight loss] group and 35.2% of those in the control group..In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization.
A follow-up of this study found that the lifestyle intervention in anovulatory women resulted in more spontaneous conceptions but made no difference in live birth rates.

The benefits of weight loss before fertility treatment are mixed. While some people of size do find increased success with spontaneous conception with a modest weight loss, other people of size do not. To blithely suggest that a 5-10% weight loss is all it takes to conceive is insensitive and unrealistic. It may help some; for others it may be a waste of valuable time. Weight loss can be offered to larger women if they are interested since it helps some achieve pregnancy, but the choice must be left up to them, not mandated.

Furthermore, time is a complicating issue. If women put off pregnancy to pursue weight loss, they are losing some of their most fertile years. It can take a long time to lose weight down to required BMI cutoffs. As one critic noted:
Restricting fertility treatment on the grounds of BMI would cause stigmatization and lead to inequity...Time lost and poor success of conventional weight loss strategies would jeopardize the chances of conception for many women.
Surveys suggest that very few women in their 30s are willing to delay seeking fertility treatment in order to pursue weight loss. They know that advancing age is a far more important risk factor than weight.

Others are unwilling to pursue weight loss because even a small loss often results in long-term weight gain rebound and they are unwilling to risk that, especially in pregnancy. A high drop-out rate in weight-loss-for-fertility programs is an additional problem, suggesting that many of these programs are not sustainable or practical.

As a result, there are some doctors who suggest an emphasis on good nutrition and exercise a few months before treatment is more effective than a weight loss emphasis.:
Lifestyle modifications, in particular a healthy diet and exercise during the 3-6 months before conception and during treatment, should result in better outcomes than requiring weight loss before fertility treatments.
This is compatible with a Health At Every Size® approach. Focus on lifestyle and habits, not the scale. Healthy habits are very important before pregnancy but they doesn't necessarily result in weight loss.

Perceived Risks of Obese Pregnancies

Headline from The National Post, 2016
Many fertility docs justify denying treatment to high BMI women because of the perceived risks of pregnancy at larger sizes. They are concerned that the risks of an Assisted Reproduction Technology pregnancy will magnify the risks of a high BMI pregnancy, creating an extremely unhealthy outcome. However, research shows that the two risks are generally not synergistic.

Some doctors believe that fat women are at SUCH high risk that they can't possibly have a healthy pregnancy or a healthy baby. While that's simply not true, it is a strongly held belief of many fertility doctors. Toronto fertility specialist Dr. Carl Laskin says:
“To me, it’s a medical issue. It is not a discrimination issue. [Obese] women are running risks in pregnancy, and if they’re running risks in pregnancy, why should you be helping them get pregnant?” Dr. Laskin has a BMI cut off of 35. “Mine is a brick wall,” he said. "Other clinics will go as high as 40. Some have no cut off."
Bill Ledger, a professor of Reproductive Medicine at Sheffield University in the U.K., reflects the extremism of some doctors' beliefs:
Doctors shouldn't be helping women have a pregnancy that's at a high risk of going horribly wrong. 
Many reproductive endocrinologists (REs) feel that "it would be unethical to help a fat woman get pregnant."  From a comment left on my blog in a past post:
I just went to a gynecologist this past week ...I was told, quite directly, that she would not and nor would any doctor in my HMO take me on since my BMI would make the pregnancy too high risk to myself and a fetus.
An article from 2016 has the doctor throwing down the Fat Death Card (if you get pregnant you'll probably die so we mustn't help you):
One woman recounted a fertility doctor telling her, “Gals your size, OK, mortality rates are higher. So I go ahead and intervene, help you get pregnant here. Then you go down to (a birthing ward). And then, boom! Pulmonary embolism.”
Again, this goes back to risk hyperbole. People of size are more at risk for blood clots, some of which can go to the lung (pulmonary embolism), and that is potentially lethal. But the actual incidence of such incidents is quite low. Furthermore the risk can be lowered with good care by using blood thinners when indicated, not doing cesareans unless truly needed, keeping women as mobile as possible all throughout pregnancy and afterwards, and increasing postpartum surveillance for blood clots in women at increased risk.

Furthermore, the argument about risk is a spurious argument because it is not applied equally. 

Doctors justify denying fertility treatment because women of size do have a higher rate of pregnancy and birth complications, but they weaken their argument by not applying it equitably:
...the objection is that it excludes a specific patient category on grounds that are not applied to treatment of others with comparable risks.
In other words, there are many other groups (like older women, people with certain medical conditions) that have similar or higher risks for complications but these groups are NOT denied access to fertility treatment. Only fatness is penalized in such an across-the-board way. As one review put it:
...a higher risk than the mean IVF population does not mean that it is irresponsible to take that risk. It is a question of proportionality: a higher risk can still be acceptable in light of the gain a woman can expect from treatment. Through the same reasoning IVF is thought acceptable in other women who are at increased risk of pregnancy complications because of medical conditions. Women with diabetes mellitus have an increased risk of hypertensive disorders and congenital abnormalities, macrosomia, stillbirth and premature labour...Diabetes mellitus is, however, not an exclusion criterion for fertility treatment.
Another recent review agreed:
Given that patients with, for example, diabetes or previous pre-eclampsia, who are at higher risks than many obese women, are allowed treatment on the basis of individualized and well-informed decision-making, we think there is no justification for taking a different line with regard to BMI.
Although fertility doctors like to pretend that denial of treatment is based on their concern for risks, they don't apply these rules equally among groups. The same standards are not applied to other women at higher risk for complications; only the obese are targeted. 

Research also shows that while some risks are increased in people of size, the increase in risk is moderate, and many women of size actually have perfectly healthy pregnancies and births. Furthermore, group statistics cannot predict any one person's outcome. Denying fertility treatment based only on weight limits or BMI means that many pregnancies that would have had normal and healthy outcomes will never occur.

Some experts refute the idea that BMI should be used as a surrogate for unacceptable risk levels:
Dr. Cheung plans to argue that studies also show IVF does not pose unacceptable risks for heavy women, and that BMI alone is not a good measure of which patients face the highest risks. Age, he said, is "by far the strongest indicator" of success and dangers.
An article highlighting the Canadian debate agrees:
But to Dr. Yoni Freedhoff, a specialist in weight control at the Ottawa Bariatric Medical Institute, that’s part of an “insidious” health care practice. 
“It would seem to me that this ‘you’re too fat to have IVF’ policy probably is in part started as patient safety, but ultimately it reflects weight bias,” he said. 
Freedhoff, who’s advised assisted reproduction patients needing to lose weight, doesn’t dispute that excess pounds can cause additional risks. What he doesn’t understand is why weight might exclude women from fertility treatment, but other factors that have been shown to adversely affect pregnancy — such as smoking or advanced age — are not perceived as equally damaging.
Ethics and Eugenics Questions

Headline from The Independent, 2018
Infuriatingly, in some areas, helping an obese woman with fertility is seen as malpractice and authorities forbid or strongly discourage allowing fertility docs to treat women of size. According to guidelines in the UK:
Fertility clinics should defer treating obese women until they have lost weight through dieting, exercise or surgery, according to guidelines published today. Under the recommendations, clinics are advised to begin treatment on severely overweight women only once they have reduced their body mass index (BMI) to below 35. Women under 37 years of age should reduce their weight further, to a BMI of less than 30, the guidelines state.
Here's a story from a woman in Australia:
I’ve been to two fertility specialists and neither of them will give us any fertility treatment until I have a BMI of under 35 (99kg). Nothing to do with my chances of getting pregnant; they say it’s an ethical matter, that obesity itself is enough of a health challenge for the body without adding the impact of pregnancy. Getting an obese woman pregnant would be seen as doing harm. The second OBGYN informed me it’s a state-wide guideline according to the Fertility Council which covers public & private health.
Although there are fertility docs out there who believe that it's wrong to deny fertility treatment to fat women, BMI restrictions are common in many fertility practices and some government healthcare.

In New Zealand, Australia, and Canada, there are guidelines in place/ being proposed to prevent women over a BMI of 35 from accessing fertility treatment. In the U.K., women under the age of 37 must have a BMI of no more than 30. In the U.S., guidelines are more individualized, but many clinics have policies in place that bar fertility treatment above a certain BMI, usually 35.

And now things are going even further. Some areas of the U.K. are proposing limiting fertility treatments to women whose male partners have a BMI over 30. The woman can have a "normal" BMI which would ordinarily get her IVF, but if her partner is fat, she doesn't qualify anymore. So not only can they deny treatment to fat women, but to fat men and any woman with a fat male partner.

Some fertility experts  recognize the major ethical problems with denying heavier people access to fertility treatment. An article about proposed BMI limitations on fertility treatment in Canada notes:
...It's ethically troubling," said the University of Manitoba's Arthur Schafer, director of the Centre for Professional and Applied Ethics. "In our society, the decision to procreate is left to the individual – so why would it be appropriate for the doctors to usurp those rights for women who are obese." 
Doctors would only be justified, he says, if they could "honestly, hand-on-heart say," that the safety risks are so great "that no reasonable fat woman would want to conceive a baby in this way." 
"I'm not sure the fertility industry or association can really defend a blanket exclusion on obese women having access to assisted reproduction."
Intersectional stigma applies here too. Another article from Australia notes that the impact of these policies is often discriminatory towards various racial groups and poorer people:
"They need to recognise that there's harm in doing nothing. Women who are unable to have children, there's a much higher risk of depression and anxiety and a doubling in the suicide rate. So doing nothing is not necessarily doing the best thing." 
The guidelines, he claims, can be classified as discrimination."Especially when you consider the low socio-economic group," he said. 
"The Indigenous patients have a lot higher incidents of obesity than the general population, so you're almost discriminating against those two disadvantaged groups in this particular policy. "Obviously that wasn't the original intent, but that is a potential end product of that."
Here is what one group of experts argues in response to the usual excuses for denying fertility treatment based on BMI (my emphasis):
Obesity is associated with a reduction in fertility treatment success and increased risks to mother and child. Therefore guidelines of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) suggest that a body mass index exceeding 35 kg/m2 should be an absolute contraindication to assisted fertility treatment such as in vitro fertilisation IVF. 
In this paper we challenge the ethical and scientific basis for such a ban. Livebirth rates for severely obese women are reduced by up to 30%, but this result is still far better than that observed for many older women who are allowed access to IVF. This prohibition is particularly unjust when IVF is the only treatment capable of producing a pregnancy, such as bilateral tubal blockage or severe male factor infertility. 
Furthermore, the absolute magnitude of risks to mother or child is relatively small, and while a woman has a right to be educated about these risks, she alone should be allowed to make a decision on proceeding with treatment. We do not prohibit adults from engaging in dangerous sports, nor do we force parents to vaccinate their children, despite the risks. Similarly, we should not prohibit obese women from becoming parents because of increased risk to themselves or their child. 
Finally, prohibiting obese women's access to IVF to prevent potential harms such as 'fetal programing' is questionable, especially when compared to that child never being born at all. As such, we believe the RANZCOG ban on severely obese women's access to assisted reproductive treatment is unwarranted and should be revised.
Amen to that. Now if only the health authorities would listen. Unfortunately, they seem to be going in the opposite direction, getting more stringent in their weight-related restrictions, as seen in the U.K. limits on male partners too.

Summary


Headline from abc.news.au, 2017
A few brave medical professionals are speaking out about the discrimination happening in fertility treatment despite tremendous pressure from their colleagues. There have been a number of articles published recently in OB journals questioning the ethics of BMI restrictions but so far, none of the national guidelines have changed. And as noted in the U.K., things seem to have gotten even worse.

Bottom line, denying fat people access to fertility treatment is another form of keeping fat people from having children, but many doctors resist acknowledging the implications of these restrictions. They tell themselves they are protecting their patients with these guidelines. They tell themselves it's all about the risks, yet other groups with similar risks are not penalized. They refuse to acknowledge that they are infantilizing larger-bodied people and taking away their personal autonomy over crucial life decisions.

Authorities think that they are doing fat women a favor by insisting they lose weight before pregnancy, yet by insisting on such weight loss they deny women timely intervention when fertility treatments are most likely to succeed. The number of people who lose weight to a "normal" BMI and keep it off is quite small. When authorities insist on a much lower BMI as a requirement for treatment, they basically are keeping fat people from having children. Intentional or not, this is Eugenics.

Denial of treatment is based on weight bias, the assumption that all fat people voluntarily brought on their weight through poor health habits, sloth, and gluttony, and would perpetuate those bad habits to the next generation. Doctors assume that fatness is easily solved through altering health habits and exercising a little more willpower, but this argument does not hold up under scrutiny.

Research is very clear that most people are unable to lose weight and keep it off long-term, so denying treatment until someone reaches an "ideal BMI" or even a 5-10% reduction is unrealistic and delays fertility treatment until it may be too late. As some experts note;
Age trumps everything, so if your plan is going to make these women lose weight, the time that might take them if they’re older is going to be way more significant than any potential benefit in terms of weight loss.
Weight loss surgery does reduce BMI, but research shows significant trade-offs. There are reduced risks for gestational diabetes and large babies, but also increased risks of prematurity, too-small babies, and possibly neonatal mortality. There are no easy answers here.

Potential health complications is a red herring argument. The underlying reason weight has been made an automatic disqualifier is because doctors see people of size as unfit parents who will create more fat people. Sure, there are some fat people who do have poor health habits but so do many thinner women, yet they are not kept from fertility treatment. If health habits were the main concern then EVERY patient should be screened for this and used as a barrier to treatment for all sizes, yet it's only targeted to obese people.

Furthermore, many fat people have medical causes for their weight such as Polycystic Ovarian Syndrome, lipedema, hypothyroidism, etc., and these conditions can impact fertility as well. To deny people with conditions like PCOS treatment is to penalize them for their genetics. People should not be punished for their genetic vulnerabilities.

People of size should be informed of the potential risks of pregnancy at larger sizes, but in a realistic way, not through scare tactics. People of ALL sizes should be encouraged to practice healthy habits and have great nutrition, and should be counseled about their individual risks. In most cases, though, the decision on whether to proceed with fertility treatment must be the person's. The government or a group of doctors has no business controlling whether or not a person has children. It infantilizes women and takes away personal autonomy to impose such rigid guidelines.

Denying fertility treatment based on weight basically keeps a whole group of people from having children and that's always a suspicious restriction that smacks of eugenics.

Those who would deny fertility treatment based on BMI are trying to be the gatekeepers of who are "allowed" to reproduce; this is another insidious form of eugenics and must STOP.


Resources

If you are experiencing fertility issues, here is a brief set of links to resources that might be helpful:
References

*The full list of references for this post are far too long to include. Instead, here are a few key references and quotes. The other references are scattered throughout the article and have links to the original sources and studies. 

Studies Critical of BMI Limits on Fertility Treatment

Should obese women's access to assisted fertility be limited? A scientific and ethical analysis. Tremellen et al. 2017 Aust N Z J Obstet Gynaecol https://www.ncbi.nlm.nih.gov/pubmed/28299785
Quote: "The absolute magnitude of the risks to mother or child is relatively small, and while a woman has a right to be educated about these risks, she alone should be allowed to make a decision on proceeding with treatment...we should not prohibit obese women from becoming parents because of the increased risk to themselves or their child...."
Should access to fertility treatment be determined by female body mass index? Pandey et al., 2010 Human Reproduction.  www.pubmed.gov/20129994
Quote: "Restricting fertility treatment on the grounds of BMI would cause stigmatization and lead to inequity...Time lost and poor success of conventional weight loss strategies would jeopardize the chances of conception for many women."
It is not justified to reject fertility treatment based on body mass index. Koning et al., 2017. Human Reproduction Open. https://academic.oup.com/hropen/article/2017/2/hox009/4049574
Quote: "Given that patients with, for example, diabetes or previous pre-eclampsia, who are at higher risks than many obese women, are allowed treatment on the basis of individualized and well-informed decision-making, we think there is no justification for taking a different line with regard to BMI."
Should overweight or obese women be denied access to ART?: Comment by: Ahmed Badawy, Middle East Fertility Society Journal, 2013. https://www.sciencedirect.com/science/article/pii/S1110569013001106
Quote: "Those who are choosing to postpone childbearing for the weight reduction should balance the negative effects of aging versus obesity on fertility and perinatal outcomes... there is no strong evidence for the association between obesity and live birth in infertile women. Thus, there is insufficient proof to refute women fertility treatment on grounds of BMI."
We need to stop discriminating against plus-size pregnant women. Raina Delisle, Today's Parent, 2017.  https://www.todaysparent.com/pregnancy/pregnancy-health/we-need-to-stop-discriminating-against-plus-size-pregnant-women/

Women with obese male partners will be denied IVF treatment, rules NHS group. Tom Embury-Dennis. Independent, 2018. https://www.independent.co.uk/news/health/women-obese-men-denied-ivf-treatment-bmi-30-bath-north-east-somerset-ccg-a8248061.html

Should high BMI be a reason for IVF treatment denial? Friedler et al., 2017 Gynecological Endocrinology  https://www.ncbi.nlm.nih.gov/pubmed/28531369 
Quote: "The results of our relatively large retrospective study did not demonstrate a significant impact of BMI on the ART cycle outcome. Therefore, BMI should not be a basis for IVF treatment denial."
Randomized Trial of a Lifestyle Program in Obese Infertile Women. Mutsaerts et al., 2016 New England Journal of Medicine https://www.ncbi.nlm.nih.gov/pubmed/27192672
...The primary outcome [live birth rate] occurred in 27.1% of the women in the intervention [weight loss] group and 35.2% of those in the control group (rate ratio in the intervention group, 0.77; 95% confidence interval, 0.60 to 0.99). CONCLUSIONS: In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization.
Mr. Fertility Authority, Tear Down That Weight Wall! Hum Reproduction 2016 Dec;31(12):2662-2664. Epub 2016 Oct 19. Legro RS1. PMID: 27798043  Full text here
Discussion of the 2016 NEJM study above and subsequent subanalysis. Quote: "The impression from these epidemiologic studies and the smaller interventional trials is that obese women are damned if they do lose weight prior to pregnancy and damned if they don't. As the LIFEstyle study indicates, dropout rates with lifestyle modification are high (20%), the average amount of weight lost is modest (4.4 kg) and most women will not achieve the targeted weight loss (62%). Furthermore, women who participate, regardless of age, initial BMI and ovulatory status, will experience cumulative lower rates of a healthy baby... pending further studies, these cumulative data suggest that weight limits used to deny women access to fertility care are not only arbitrary, but discriminatory, and clearly not evidence-based.